Charge-detection mass spectrometer measures individual high-mass particles, enabling direct determination of mass for heterogeneous biomolecules by electrostatic linear ion trap capturing both m/z and charge for each ion for accurate characterization of large species such as viral vectors, protein assemblies, and other megadalton-scale complexes. The system supports analysis of samples beyond 100 MDa and provides single-particle data suitable for purity assessment and structural evaluation.
